Last updated on September 2nd, 2020 at 11:51 pm
Cordyceps is a herb that has been used for thousands of years to treat a myriad of illnesses. It increases energy, improves mood, and is said to boost the immune system.
|Also Known As||Cordycep sinensis, cordyceps militaris, CS-4, CS-5, Cordymax|
|Main benefits as seen in research|
|Typical route||Orally with food|
|Typical dose||750 mg standardized to 8% cordycepin|
|Half-life||30 minutes (In rat blood. Brain half-life may be longer)|
|Mechanism of action||Affects dopamine and noradrenaline|
Increases AMPA receptor activity
|Where to Buy|| Pure Nootropics|
iHerb – Capsules only
Cordyceps sinensis is a fungus that has been used for centuries to treat a variety of different health problems. It has strong antioxidant effects, improves energy and decreases fatigue, decreases stress, fatigue, and cholesterol, and even reduces some of the effects of aging. It may be able to increase dopamine levels, particularly in the elderly or depressed. Interestingly, it may have the possibility to extend lifespan in humans as several studies on animals have shown a reliable increase in lifespan.
In terms of its mechanism of action, not much research has been done. Though, from the current studies it is known to increase dopamine and noradrenaline activity as well as AMPA receptor activity. It increases several endogenous antioxidants.
Summary of benefits
|Memory and learning||Improved||N/A||Mice|
|Depression||Rapid decrease in symptoms||N/A||Mice|
|Testosterone||No change||600 mg - 2.4 g||Healthy males|
|Antioxidants||Increased: superoxide dismutase, glutathione peroxidase and catalase||N/A||Mice|
|Cancer||Decreased proliferation, cell growth, and increased apoptosis||N/A||In-vitro studies|
Memory and learning
When mice are aged artificially using d-galactose, cordyceps is able to improve their memory and learning in the water maze and step-down test. Likewise, in mice with memory impairments cordyceps is able to significantly improve their memory and learning.
In one study, it was shown that mice subjected to the tail suspension test had dose-dependent decreases in immobility time indicating an antidepressant-like effect. In another, it significantly decreased depression just 45 minutes after treatment, in a similar way to that of ketamine. Furthermore, not only were its antidepressant effects faster than that of imipramine, but they were also stronger. The antidepressant effect remained after 5 days of treatment.
Research has shown cordyceps may have antidepressant effects similar to that of ketamine.
When rats are exposed to stress, their organs grow in size, specifically the adrenals, spleen, thymus, and thyroid. Cordyceps given for 8 days is able to prevent this weight increase indicating an anti-stress effect.
In 16 healthy adult males, 2.4 g of cordyceps taken for 8 weeks had no effect on strength and failed to affect testosterone levels. Likewise, a combination of 1400 mg of rhodiola crenulata and 600 mg of cordyceps sinensis taken for 2-weeks failed to alter testosterone levels in 9 healthy males.
A double-blind study employing 8 subjects found a combination of cordyceps sinensis and rhodiola rosea to have no effect on muscle tissue oxygen saturation nor VO2 max. A similar study with 17 competitive athletes used a formula containing 1000 mg of cordyceps sinensis, 300 mg of rhodiola rosea, and 800 mg of calcium, electrolytes(sodium and potassium), chromium, adenosine, and ribose. After 2 weeks, there was no significant improvement in exercise performance. Similarly, another study using 22 male cyclists found a high dose of 3 g of cordyceps to have no effect on effect on endurance exercise performance nor aerobic capacity.
In contrast to these findings, a study using 18 healthy males training at high altitude (2200 m) found a combination of 1400 mg of rhodiola crenulata and 600 mg of cordyceps sinensis to markedly increase exhaustive run time. In a study involving 36 male sedentary subjects, cordyceps alone was able to improve energy and reduce fatigue during exercise compared to placebo.
On the other hand, a double-blind study involving 20 healthy subjects aged 50-75 years found an odd 333 mg of CS-4 to significantly improve exercise performance after 12 weeks of treatment. Likewise, 37 healthy Chinese elders taking 3 g/day had significant improvements in oxygen uptake after 6 weeks of treatment.
In rats, it’s able to improve swimming endurance from 75 minutes to 90 minutes by decreasing fatigue.
In athletes, cordyceps has no benefit on exercise performance. But, in the elderly and sedentary adults, it significantly improves energy and decreases fatigue.
Cordyceps is able to increase superoxide dismutase, glutathione peroxidase and catalase activity and demonstrates strong antioxidant properties. All three are very powerful antioxidants. Additionally, lipid peroxidation and monoamine oxidase activity are reduced. Monoamine oxidase can give rise to free radicals when the metabolites react with certain compounds.
Cordyceps is able to greatly reduce oxidative stress by increasing endogenous antioxidant activity and decreasing the activity of monoamine oxidase.
Cordyceps is able to improve a number of parameters in mice aged artificially with d-galactose. It improves memory and learning, increases several powerful antioxidants, and increases libido castrated rats.
Cordyceps is able to increase the lifespan of fruit flies in addition to having an anti-fatigue effect.
Cordyceps sinensis is able to decrease total cholesterol, increase HDL cholesterol, and decrease VLDL cholesterol in mice given a high-cholesterol diet. In rats exposed to stress, it’s able to prevent the increase in total cholesterol.
In mice with diabetes, it increases HDL/LDL ratios after 4 weeks of treatment.
Cordyceps appears to be a viable treatment for diabetes in animals. It reliably reduces blood sugar in a dose-dependent manner. Furthermore, it protects pancreatic beta cells and the kidneys, two organs that often suffer damage as a result of diabetes. What’s more is after 8 weeks of treatment it decreases weight gain associated with diabetes. Insulin levels are increased by cordyceps, suggesting it’s either increase insulin release or decreasing its metabolism (breakdown).
In an in vitro study, human leukemic cells given cordyceps had a growth inhibition of 78-83%. Cordyceps was able to increase the activity of interferon and tumour necrosis factor alpha, which is thought to be responsible for the anticancer effects seen. Human endometrial (lining of uterus) cancer cells showed decrease proliferation (growth) when administered either cordyceps, Ganoderma lucidum, or Agaricus. Likewise, human lung adenocarcinoma cells had decreased proliferation, and increased apoptosis (programmmed cell death). And as with the human leukemic study, levels of tumour necrosis factor alpha were increased.
In living mice, it’s able to dose-dependently decrease tumour size and increase lifespan.
Cordyceps exhibits a protective effect on blood cells when mice are exposed to radiation.
Pain, inflammation, nitric oxide, and angiogenesis (growth of new blood vessels) are all decreased by cordyceps.
Mechanism of action
There have been no studies done in humans to assess its mechanism of action.
Animals and lab studies
Dopamine and noradrenaline
Mice given cordyceps experienced an antidepressant-like effect that was mediated by a dopaminergic and noradrenergic action, though its not clear exactly how. Interestingly, depletion of serotonin does not affect the antidepressant-like effects of cordyceps. In rats, its able to increase dopaminergic activity by increasing tyrosine hydroxylase (TH) levels in the brain and stomach. TH is an enzyme that’s crucial for the production of dopamine.
In aged mice, it’s able to decrease monoamine oxidase (MAO) activity, specifically that of MAO-B. This enzyme decreases dopamine and phenethylamine (PEA) levels in the brain by binding to the neurotransmitter and metabolizing it. PEA is an endogenous dopamine and noradrenaline releaser that’s similar to amphetamine. It has a very short half-life because of MAO-B, but decreasing MAO-B levels increases PEA levels. Similarly, in mice aged with d-galactose, it’s able to decrease monoamine oxidase activity.
Cordyceps is able to increase dopamine and noradrenaline activity by increasing tyrosine hydroxylase levels, modulating MAO-B, and through an unknown mechanism.
Aside from increasing dopaminergic and noradrenergic activity, its antidepressant effects are also attributed to a rapid increase in AMPA receptor activity. In both the prefrontal cortex and the hippocampus, an enhancement of AMPA signaling is seen just 45 minutes after treatment. The effect lasts up to 5 days of treatment. Its effects are akin to that of ketamine which acts via the AMPA receptors in the hippocampus and the prefrontal cortex to upregulate mTOR and BDNF. Both mTOR and BDNF increase cell growth and proliferation which in turn increases neurogenesis.
Cordyceps militaris was found to inhibit acetylcholinesterase activity, an enzyme that breaks down acetylcholine. This suggests it can increase acetylcholine levels, but to what degree is not yet known.
In mice, cordyceps is able to protect cells from damage by radiation by acting as an antioxidant. However, cordycepin does not appear to be an antioxidant and it seems a polysaccharide found in cordyceps is at least partially responsible for the antioxidant activity.
Cordyceps sinensis vs Cordyceps militaris
When buying cordyceps you may come across two different versions, sinensis and militaris. There isn’t much difference between these two herbs. They both contain cordycepin, the active ingredient of cordyceps, and several studies have shown they are of equal potency in terms of their antioxidant, anti-inflammatory, pain reducing, nitric oxide inhibiting, and anti-angiogenic properties. Though, militaris is higher in cordycepin content and was shown to be more effective at lowering blood glucose than sinensis. In practice, however, there should not be much difference in the benefits these herbs provide.
It should combine well with rhodiola to create a synergistic effect on mood, energy, and cognition. Both herbs work via a completely different mechanism thus there should not be any interaction between the two.
No studies have been done on humans to assess the safety of cordyceps in the long-term. However, it has been used for thousands of generations with no reports of dangerous side effects
- Ji, Deng-Bo et al. “Antiaging Effect of Cordyceps Sinensis Extract.” Phytother. Res. Phytotherapy Research, vol. 23, no. 1, 2009, pp. 116–122. doi:10.1002/ptr.2576.
- Dong, Yunzi et al. “Cordyceps Sinensis Cs-5 Improves Memory and Learning Abilities in a Dysmnesia Model (684.1).” The FASEB Journal, vol. 28, no. 1 Supplement, 1 Apr. 2014,
- Nishizawa, Koji et al. “Antidepressant-Like Effect of Cordyceps Sinensis in the Mouse Tail Suspension Test.” Biol. Pharm. Bull. Biological &Amp; Pharmaceutical Bulletin, vol. 30, no. 9, 2007, pp. 1758–1762. doi:10.1248/bpb.30.1758.
- Hsu, C C et al. “No Effect Of Cordyceps Sinensis Supplementation On Testosterone Level And Muscle Strength In Healthy Young Adults For Resistance Training.” Biol Sport Biology of Sport, vol. 28, no. 2, Dec. 2011, pp. 107–110. doi:10.5604/942739.
- Colson, Sheree N. et al. “Cordyceps Sinensis- And Rhodiola Rosea-Based Supplementation In Male Cyclists And Its Effect On Muscle Tissue Oxygen Saturation.” Journal of Strength and Conditioning Research, vol. 19, no. 2, 2005, pp. 358–363. doi:10.1519/00124278-200505000-00020.
- Earnest, Conrad P. et al. “Effects of a Commercial Herbal-Based Formula on Exercise Performance in Cyclists.” Medicine &Amp; Science in Sports &Amp; Exercise, vol. 36, no. 3, 2004, pp. 504–509. doi:10.1249/01.mss.0000125157.49280.af.
- Parcell, Allen C. et al. “Cordyceps Sinensis (CordyMax Cs-4) Supplementation Does Not Improve Endurance Exercise Performance.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 14, no. 2, 2004, pp. 236–242. doi:10.1123/ijsnem.14.2.236.
- Chen, Chung-Yu et al. “Rhodiola Crenulata- and Cordyceps Sinensis -Based Supplement Boosts Aerobic Exercise Performance after Short-Term High Altitude Training.” High Altitude Medicine &Amp; Biology, vol. 15, no. 3, 2014, pp. 371–379. doi:10.1089/ham.2013.1114.
- Nagata, Akira et al. “Supplemental Anti-Fatigue Effects Of Cordyceps Sinensis (Tochu-Kaso) Extract Powder During Three Stepwise Exercise Of Human.” Tairyoku Kagaku Jpn. J. Phys. Fitness Sports Med. Japanese Journal of Physical Fitness and Sports Medicine, vol. 55, no. Supplement, 2006, doi:10.7600/jspfsm.55.s145.
- Chen, Steve et al. “Effect of Cs-4 ® ( Cordyceps Sinensis ) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial.” The Journal of Alternative and Complementary Medicine, vol. 16, no. 5, 2010, pp. 585–590. doi:10.1089/acm.2009.0226.
- Yi, Xiao et al. “Randomized Double-Blind Placebo-Controlled Clinical Trial and Assessment of Fermentation Product of Cordyceps Sinensis (Cs-4) in Enhancing Aerobic Capacity and Respiratory Function of the Healthy Elderly Volunteers.” Chinese Journal of Integrative Medicine Chin. J. Integr. Med., vol. 10, no. 3, 2004, pp. 187–192. doi:10.1007/bf02836405.
- Yan, Wenjuan et al. “Anti-Fatigue Property of Cordyceps Guangdongensis and the Underlying Mechanisms.” Pharmaceutical Biology, vol. 51, no. 5, 2013, pp. 614–620. doi:10.3109/13880209.2012.760103.
- Tan, Ning-Zhi et al. “The Lifespan-Extending Effect of Cordyceps Sinensis Cs-4 in Normal Mice and Its Molecular Mechanisms.” The FASEB Journal, vol. 25, no. 1 Supplement, 0ADAD, pp. 599.1–599.1.
- Yan, Xiao-Feng et al. “Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors.” Phytother. Res. Phytotherapy Research, vol. 27, no. 11, 2012, pp. 1597–1604. doi:10.1002/ptr.4899.
- Li, S.p. et al. “Anti-Oxidation Activity of Different Types of Natural Cordyceps Sinensis and Cultured Cordyceps Mycelia.” Phytomedicine, vol. 8, no. 3, 2001, pp. 207–212. doi:10.1078/0944-7113-00030.
- Lo, Hui-Chen et al. “Anti-Hyperglycemic Activity of Natural and Fermented Cordyceps Sinensis in Rats with Diabetes Induced by Nicotinamide and Streptozotocin.” The American Journal of Chinese Medicine Am. J. Chin. Med., vol. 34, no. 05, 2006, pp. 819–832. doi:10.1142/s0192415x06004314.
- Lo, Hui-Chen et al. “The Anti-Hyperglycemic Activity of the Fruiting Body of Cordyceps in Diabetic Rats Induced by Nicotinamide and Streptozotocin.” Life Sciences, vol. 74, no. 23, 2004, pp. 2897–2908. doi:10.1016/j.lfs.2003.11.003.
- Kan, Wei-Chih et al. “Effects of Extract from Solid-State FermentedCordyceps Sinensison Type 2 Diabetes Mellitus.” Evidence-Based Complementary and Alternative Medicine, vol. 2012, 2012, pp. 1–10. doi:10.1155/2012/743107.
- Li, S.p. et al. “Hypoglycemic Activity of Polysaccharide, with Antioxidation, Isolated from Cultured Cordyceps Mycelia.” Phytomedicine, vol. 13, no. 6, 2006, pp. 428–433. doi:10.1016/j.phymed.2005.02.002.
- Hahne, Jens et al. “The Effect of Cordyceps Extract and a Mixture of Ganoderma Lucidum/Agaricus Blazi Murill Extract on Human Endometrial Cancer Cell Lines in Vitro.” Int J Oncol International Journal of Oncology, May 2014, doi:10.3892/ijo.2014.2414.
- Mingwei, Chen et al. “Pro-Apoptotic Effects of Paecilomyces Hepiali, a Cordyceps Sinensis Extract on Human Lung Adenocarcinoma A549 Cells in Vitro.” J Can Res Ther Journal of Cancer Research and Therapeutics, vol. 7, no. 4, 2011, p. 421. doi:10.4103/0973-1482.92007.
- Chen, Yu-Jen et al. “Effect of Cordyceps Sinensis on the Proliferation and Differentiation of Human Leukemic U937 Cells.” Life Sciences, vol. 60, no. 25, 1997, pp. 2349–2359. doi:10.1016/s0024-3205(97)00291-9.
- Park, Sang Eun et al. “Antitumor Activity of Water Extracts From Cordyceps Militaris in NCI-H460 Cell Xenografted Nude Mice.” Journal of Acupuncture and Meridian Studies, vol. 2, no. 4, 2009, pp. 294–300. doi:10.1016/s2005-2901(09)60071-6
- Lin, Chun-Chih et al. “Radiation Protective Effects of Cordyceps Sinensis in Blood Cells.” Tzu Chi Medical Journal, vol. 19, no. 4, 2007, pp. 226–232. doi:10.1016/s1016-3190(10)60020-1.
- Koh, Jong-Ho et al. “Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps Sinensis.” Biol. Pharm. Bull. Biological &Amp; Pharmaceutical Bulletin, vol. 26, no. 1, 2003, pp. 84–87. doi:10.1248/bpb.26.84.
- Koh, Jong-Ho et al. “Antifatigue and Antistress Effect of the Hot-Water Fraction from Mycelia of Cordyceps Sinensis.” Biol. Pharm. Bull. Biological &Amp; Pharmaceutical Bulletin, vol. 26, no. 5, 2003, pp. 691–694. doi:10.1248/bpb.26.691.
- Sapkota, Kumar et al. “Enhancement of Tyrosine Hydroxylase Expression by Cordyceps Militaris.” Open Life Sciences, vol. 5, no. 2, Jan. 2010, doi:10.2478/s11535-010-0010-8.
- Zhang, Zhenya et al. “Chemical Composition and Bioactivity Changes in Stale Rice after Fermentation with Cordyceps Sinensis.” Journal of Bioscience and Bioengineering, vol. 106, no. 2, 2008, pp. 188–193. doi:10.1263/jbb.106.188.
- ang YH, Ye J, Li CL, Cai SQ, Ishizaki M, Katada M. [An experimental study on anti-aging action of Cordyceps extract]. Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):773-6. Chinese. PubMed PMID: 15506292.
- Li, Bai et al. “3’-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.” International Journal of Neuropsychopharmacology IJNPPY, vol. 19, no. 4, June 2015, doi:10.1093/ijnp/pyv112.
- Zhou, W. et al. “Ketamine-Induced Antidepressant Effects Are Associated with AMPA Receptors-Mediated Upregulation of MTOR and BDNF in Rat Hippocampus and Prefrontal Cortex.” European Psychiatry, vol. 29, no. 7, 2014, pp. 419–423. doi:10.1016/j.eurpsy.2013.10.005.
- Akinfiresoye, Luli, and Yousef Tizabi. “Antidepressant Effects of AMPA and Ketamine Combination: Role of Hippocampal BDNF, Synapsin, and MTOR.” Psychopharmacology, vol. 230, no. 2, Apr. 2013, pp. 291–298. doi:10.1007/s00213-013-3153-2.
- Yu, Hui Mei et al. “Comparison of Protective Effects between Cultured Cordyceps Militaris and Natural Cordyceps Sinensis against Oxidative Damage.” J. Agric. Food Chem. Journal of Agricultural and Food Chemistry, vol. 54, no. 8, 2006, pp. 3132–3138. doi:10.1021/jf053111w.
- Zhang, Guoqing et al. “Hypoglycemic Activity of the Fungi Cordyceps Militaris, Cordyceps Sinensis, Tricholoma Mongolicum, and Omphalia Lapidescens in Streptozotocin-Induced Diabetic Rats.” Appl Microbiol Biotechnol Applied Microbiology and Biotechnology, vol. 72, no. 6, 2006, pp. 1152–1156. doi:10.1007/s00253-006-0411-9.
- Kim, H.o., and J.w. Yun. “A Comparative Study on the Production of Exopolysaccharides between Two Entomopathogenic Fungi Cordyceps Militaris and Cordyceps Sinensis in Submerged Mycelial Cultures.” J Appl Microbiol Journal of Applied Microbiology, vol. 99, no. 4, 2005, pp. 728–738. doi:10.1111/j.1365-2672.2005.02682.x.
- Won, So-Young, and Eun-Hee Park. “Anti-Inflammatory and Related Pharmacological Activities of Cultured Mycelia and Fruiting Bodies of Cordyceps Militaris.” Journal of Ethnopharmacology, vol. 96, no. 3, 2005, pp. 555–561. doi:10.1016/j.jep.2004.10.009.
- Tsai, Yung-Jen et al. “Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent of Cordyceps Sinensis in Rat.” J. Agric. Food Chem. Journal of Agricultural and Food Chemistry, vol. 58, no. 8, 2010, pp. 4638–4643. doi:10.1021/jf100269g.
- Cho, Hyun-Jeong, et al. “Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation.” 대한의생명과학회지 10.1 (2004): 9-13.
- Tsai, Cheng-Han et al. “Finding of Polysaccharide-Peptide Complexes in Cordyceps Militaris and Evaluation of Its Acetylcholinesterase Inhibition Activity.” Journal of Food and Drug Analysis, vol. 23, no. 1, 2015, pp. 63–70. doi:10.1016/j.jfda.2014.05.006.